Pilocarpine: eye drops for treating presbyopia

Presbyopia can affect everyone at some point in their lives. Get to know one of the treatment options that may be available to you when it does.

Medically reviewed on October 15, 2025
Published on January 29, 2026
5 minute read

What is presbyopia?

A man in a button-up shirt and his wife stand in a square looking at a phone in the man’s hand

Presbyopia is a change to your vision that happens as you get older, usually starting in your 40s. Over time, you might notice you need to hold books, menus, or your phone farther away to see clearly. This is because the lens inside your eye gradually becomes less flexible, making it harder to focus on things close to you. Traditionally, this is when people would start to use reading glasses, but nowadays, you have more options, like glasses, eye drops, contact lenses, or even eye surgery.

How does pilocarpine work for presbyopia?

Icon to illustrate eye drops and its bottle

Pilocarpine is a medication that has been used for many years for other eye problems, like glaucoma. In recent years, doctors found that small doses of pilocarpine can also help with presbyopia. How does it work? When you put pilocarpine eye drops in your eyes, they cause the tiny muscles that control your pupils to contract. This creates a smaller opening for light to come through, making it easier to focus on things up close. If you’ve ever done photography, it’s similar to how a camera aperture can be narrowed to get an overall clearer picture. The effect is called “extended depth of focus.”

Could pilocarpine drops be right for you?

Not everyone with presbyopia can use pilocarpine eye drops. That’s why it’s very important to have a full eye exam before considering pilocarpine—your eye doctor will check your eye health and see if this treatment is right for you. For example, if you are at risk for retinal detachment, your doctor may be less likely to prescribe pilocarpine.

Possible side effects of pilocarpine

Like any medicine, pilocarpine eye drops can cause side effects. Some common ones to look out for include:

  • Eye irritation
  • Redness in eyes
  • Blurry vision
  • Trouble seeing in dim light
  • Headaches or eye pain

Side effects are typically mild, but it’s important to see your doctor regularly while using pilocarpine. If your side effects don’t get better or if they get worse, contact your doctor right away.

Other presbyopia treatment options

Pilocarpine drops are just one way to treat presbyopia. Other options include:

Reading glasses

These are eyeglasses designed to help people see things up close more clearly. They are easy to use and typically inexpensive. You wear them only when you need to read or do close work.

Progressive or bifocal eyeglasses

These glasses are designed to provide clear vision at more than one distance. Progressive lenses provide a gradual change in power to allow a continuous range of vision, while bifocal lenses have two distinct powers for near and distance vision. 

Contact lenses

Some contacts can correct presbyopia. With monovision contacts, you wear a different lens prescription in each eye—one lens in one eye for distance vision and another in the other eye for close-up vision. Multifocal lenses are designed to correct vision in each eye at multiple distances, allowing near, intermediate and distance vision. 

Surgery

There are surgeries that can change the shape of your cornea or replace your eye’s natural lens. These can help you depend less on glasses or contacts. Examples include LASIK, corneal inlays, or lens implants.

Questions? Contact an eye doctor.

A young female doctor smiles as she talks on the phone

Curious about treating your presbyopia with pilocarpine or other treatments? The best thing to do is talk with your eye doctor. They can check your eyes and help you understand the benefits and risks of each option.

FAQs

Frequently asked questions

What is pilocarpine and how does it help presbyopia?

Pilocarpine makes the pupil of your eye smaller. This extends your eye’s dept of focus, allowing you to see close objects better if you're presbyopic.

Is pilocarpine safe?

When used carefully under a doctor’s supervision, it is generally safe. Even so, side effects can happen, so talk to your eye doctor, who can determine if pilocarpine is an option for you.

How quickly does pilocarpine work?

Pilocarpine takes effect after a few minutes and lasts for a few hours.

Can I use pilocarpine if I have other eye problems?

You should talk to your doctor first, only they can decide if it’s appropriate for you.

Are pilocarpine eye drops available over the counter?

No, they are only available as a prescription.

What side effects might I have?

Some people get eye redness, blurred vision, or headaches. Serious side effects are rare but can occur, so reach out to your eye doctor immediately if you notice anything unusual when using pilocarpine drops.

Is pilocarpine a permanent fix?

No, pilocarpine isn’t a permanent fix. It only works while you’re using it, so you may need to apply it everyday or consider other treatment options to manage presbyopia over time.

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